Porogaramu z'ibicuruzwa

1) Inkoko z'inkoko

Igihe MMHAC (hydroxy methionine chelates y'umuringa, zinc, na manganese) byongewe mu ndyo y’inkoko z’inyama, ibyavuye mu bushakashatsi byagaragaje ko—ugereranije n’imyunyungugu gakondo idashingiye ku binyabuzima—kuba harimo MMHAC byongereye cyane ibiro by’umubiri n’imitsi y’ikibero, byongera ubushobozi bwo kugogora umuringa, kandi nta ngaruka mbi byagize ku buzima bw’impyiko cyangwa amagufwa.

Imbonerahamwe ya 1. Uburemere bwo gutunganya inyama (g/inyoni) n'amabere y'inkoko n'amabere y'inkoko z'inkoko zigaburirwa inorganic na methionine hydroxyl analogue chelated zinc, copper, na manganese ku munsi wa 42.

Ikintu	ITM	M10	T125	M30	SEM	Agaciro ka P
Ibere	684	716	719	713	14.86	0.415
Ikibero	397	413	412	425	7.29	0.078
Igiti cy'ingoma	320	335	332	340	4.68	0.058
Ikibero n'umushumi w'ingoma	717 a	748 ab	745 ab	765 b	11.32	0.050
Ikiyiko cy'ibinure	32.3	33.1	33.4	35.5	1.59	0.546
Umwijima	68.0	67.4	66.0	71.1	2.41	0.528
Umutima	18.8	18.6	19.2	19.2	0.68	0.898
Impyiko	9.49	10.2	10.6	10.6	0.51	0.413

Icyitonderwa: ITM: Imyunyu ngugu idakomoka ku bimera 110 ppm Zn nka ZnSO4 16 ppm Cu nka CuSO4 na 120 ppm Mn nka MnO kuri Ross 308 inama z'imirire;

M10: Ingano ya 40 ppm Zn 10 ppm Cu na 40 ppm Mn nk'icyelate;

T125: Imyunyu ngugu idakomoka ku bimera 110 ppm Zn nka ZnSO4 na 120 ppm Mn nka MnO kuri Ross 308 amabwiriza hamwe na 125 ppm Cu nka tribasic copper chloride (TBCC);

M30 = 40 ppm Zn, 30 ppm Cu, na 40 ppm Mn nk'ikimenyetso. Agaciro ko ku murongo umwe hamwe n'inyandiko z'imbere zitandukanye gatandukanye cyane (P < 0.05).

2) Ingurube

Ubushakashatsi bwakozwe bwagaragaje ingaruka zo gusimbuza igice kimwe cy’imyunyu ngugu idafite umwimerere hamwe n’imyunyu ngugu ya methionine hydroxy analogue chelates (MMHAC) mu mirire y’ingurube ku ngurube zombi n’ingurube zazo. Ibisubizo byagaragaje ko kongerera MMHAC bigabanya kugabanya ibiro mu mubiri w’ingurube zonsa, byongera ibiro by’ingurube ku munsi wa 18, byongera cyane urugero rwa histone acetylation mu mitsi y’amagufwa igihe cyo kuvuka, kandi bigabanya imyitwarire y’uturemangingo twinshi dufitanye isano no kubyimba no gukura kw’imitsi. Muri rusange, MMHAC yazamuye ubuzima bw’amara n’imitsi mu ngurube binyuze mu kugenzura epigenetic no gukura, yongera ubushobozi bwazo bwo gukura.

Imbonerahamwe ya 2 Ingaruka z'inyongera za chelate ya methionine hydroxy analogue mu mirire y'ingurube ku mikorere ya mRNA y'ingenzi ijyanye no kubyimba kwa jejunal mu ngurube yonsa.

Ikintu	ITM	CTM	SEM	P- agaciro
d 1 yo konsa x 10^-5
IL-8	1344	1018	178	0.193
MUC2	5380	5511	984	0.925
NF-κB (p50)	701	693	93	0.944
NF-κB (p105)	1991	1646	211	0.274
TGF-b1	Kuva mu 1991	1600	370	0.500
TNF-α	11	7	2	0.174
d 18 yo konsa x 10^-5
IL-8	1134	787	220	0.262
MUC2	5773	3871	722	0.077

Icyitonderwa: Interleukin-8 (IL-8), mucin-2 (MUC2), nuclear factor-κB (NF-κB), transforming growth factor-1 (TGF-1), na tumor necrosis factor-α (TNF-α)

ITM = amasoko asanzwe y’imyunyu ngugu idakomoka ku bimera (urugero rwa 0.2% rw’imyunyungugu iri mu mirire)

CTM = 50:50 mineral methionine hydroxy analogue chelate n'imyunyungugu idakomoka ku bimera (urugero rwa 0.2% rw'ibikubiye mu ndyo)

3)Inyama z'inka

Mu konsa inka z'amata, usimbuza kimwe cya kabiri cya sulfate y'umuringa n'ibindiumuringa wa hydroxy methioninebyongereye cyane ingano y'umuringa mu maraso, byongera ubushobozi bwo kugogora fibre ya detergent (NDF) na fibre ya aside detergent (ADF), kandi byongera umusaruro w'amata ndetse n'umusaruro w'amata wakozwe ku gipimo cya 4%. Ibi byavumbuwe bigaragaza ko gusimbuza igice kimwe sulfate y'umuringa na (HMTBA)₂-Cu mu mirire y'inka z'amata ari ingamba nziza zo kugaburira inka.

Imbonerahamwe ya 3 Ingaruka za methionine hydroxy Cu [(HMTBA)2-Cu] ku miterere y'amata y'inka

Ikintu	S	SM	M	SEM	Agaciro ka P
DMI, kg/d	19.2	20.3	19.8	0.35	0.23
Umusaruro w'amata, kg/d	28.8	33.8	31.3	1.06	0.08
Ibinure, %	3.81	3.74	3.75	0.06	0.81
Poroteyine, %	3.34	3.28	3.28	0.04	0.19
Lactose, %	4.48	4.35	4.43	0.05	0.08
SNF, %	8.63	8.84	8.63	0.05	0.33
Umusaruro w'ibinure, kg/d	1.04	1.22	1.10	0.04	0.09
Umusaruro wa poroteyine, kg/d	0.92	0.92	0.90	0.03	0.72
Umusaruro wa Lactose, kg/d	1.23	1.23	1.21	0.04	0.45
Urea N, mg/dL	18.39	17.70	18.83	0.45	0.19
4% FCM, kg/umunsi	26.1	30.1	27.5	0.91	0.06

Uburyo bwo kuvura: S = Cu sulfate gusa: 12 mg ya Cu itangwa na CuSO4 kuri kilogarama y'umunyungugu; SM = Cu sulfate na (HMTBA)2-Cu: 6 mg ya Cu itangwa na CuSO4, n'indi mg 6 ya Cu itangwa na (HMTBA)2-Cu kuri kilogarama y'umunyungugu; M = (HMTBA)2-Cu gusa: 12 mg ya Cu itangwa na (HMTBA)2-Cu kuri kilogarama y'umunyungugu.